Chromatin Boundaries and Chromatin Domains

Chromatin boundaries and chromatin domains.

Setting the Boundaries of Chromatin Domains and Nuclear Organization

The nuclear architecture of the interphase nucleus is established by laying down an intricate three-dimensional framework of higher-order chromatin structure. This arrangement is essential for the integration of complex biological processes such as DNA replication, RNA processing, and transcription. Boundary or insulator elements are emerging as key players in the establishment and maintenance ...

Chromatin boundaries: Punctuating the genome

Transcriptional enhancers are constrained to act within domains defined by boundary elements. How these elements work is a mystery. A recent study emphasizes their autonomous activity; another emphasizes their dependence on nuclear organization. Both effects need to be accounted for by any successful model.

The nuclear pore complex and chromatin boundaries.

Do LCRs Open Chromatin Domains?

key step in developing a complete model of how eukaryDouglas R. Higgs MRC Molecular Haematology Unit otic genes are regulated and has important practical implications for designing constructs that will direct fully Institute of Molecular Medicine John Radcliffe Hospital regulated expression following experimental or therapeutic gene transfer. Headington, Oxford, OX3 9DS United Kingdom Variation...